Beilstein J. Org. Chem.2018,14, 2553–2567, doi:10.3762/bjoc.14.232
-enzymatic conditions offers good understanding of their elaborate reaction mechanisms. Furthermore, bio-inspiration offers a new approach to catalytic design for green and eco-friendly molecular transformations. As part of a study based on vitamin B12 derivatives including heptamethylcobyrinate perchlorate
also described, with a focus on radical-involved reactions in terms of organic synthesis.
Keywords: dehalogenation; electrolysis; green chemistry; heptamethylcobyrinate; methyl transfer; 1,2-migration; photosensitizer; vitamin B12; Review
1. Introduction
1-1. Redox and coordination chemistry of B12
(Figure 2b). We have been exploring the utility of hydrophobic B12 model complexes, such as heptamethylcobyrinate perchlorate 1, that possess ester groups in place of the peripheral seven-amide moieties [28][29]. 1 was developed by Eschenmoser et al. as a model complex for the total synthesis of vitamin
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Graphical Abstract
Figure 1:
(a) Structure and (b) reactivity of B12.